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目的 评价Ⅱ、Ⅲ期非小细胞肺癌术前化疗加术后放疗的价值。方法 1990年 6月至1993年 12月对 5 0例Ⅱ、Ⅲ期非小细胞肺癌给予术前化疗和术后放疗 ,以同期 5 0例单纯手术治疗的肺癌患者作为对照。结果 实验组手术切除率和 5年生存率是 92 %和 42 % ,而对照组为 84%和 2 4% ,两组的 5年生存率有显著差异 (P <0 .0 5 )。实验组淋巴结转移率 ( 4 5 .7% )明显低于对照组 ( 78.6% ) ,差异有显著性 (P <0 .0 5 )。结论 术前化疗加术后放疗有助于提高非小细胞肺癌患者的长期生存率。
Objective To evaluate the value of preoperative chemotherapy and postoperative radiotherapy for stage Ⅱ and Ⅲ non-small cell lung cancer. Methods From June 1990 to December 1993, 50 patients with stage II and III non-small cell lung cancer were treated with preoperative chemotherapy and postoperative radiotherapy. Fifty patients with lung cancer undergoing simple surgical treatment during the same period were enrolled as control. Results The resection rate and 5-year survival rates in the experimental group were 92% and 42%, while those in the control group were 84% and 24%, respectively. The 5-year survival rates of the two groups were significantly different (P <0.05). The rate of lymph node metastasis (45.7%) in the experimental group was significantly lower than that in the control group (78.6%), the difference was significant (P <0.05). Conclusion Preoperative chemotherapy plus postoperative radiotherapy can help improve the long-term survival of patients with non-small cell lung cancer.