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本文采用经口痰菌定量培养,结合血及胸水培养,对我院近期148例院内外获得性支气管-肺感染进行了前瞻性的对比研究。结果表明,院内感染主要致病菌群为革兰阴性杆菌(61.3%),其次为真菌感染(13.8%)。金黄色葡萄球菌占10%,肺炎双球菌占7.5%,明显低于院外感染组(30.6%)。药敏结果表明,细菌耐药性严重,院内菌株较院外菌株耐药性强(P<0.05)。最小抑菌浓度测定表明第三代头孢菌素对肠杆菌抗菌活性较强,优于第一、第二代头孢菌素。33株绿脓杆菌对氟喹诺酮类抗生素(氟哌酸)尚未发现耐药株。
In this paper, the use of oral sputum quantitative culture, combined with blood and pleural effusion culture in our hospital 148 cases of acquired bronchial-lung infection in hospital prospective comparative study. The results showed that the main pathogens causing nosocomial infection were Gram-negative bacilli (61.3%), followed by fungal infections (13.8%). Staphylococcus aureus accounted for 10%, pneumococcus accounted for 7.5%, significantly lower than the nosocomial infection group (30.6%). Susceptibility results showed that the bacterial resistance was severe, and the in-hospital strains were more resistant than the out-of-hospital strains (P <0.05). The determination of the minimum inhibitory concentration showed that the third generation cephalosporins antibacterial activity of Enterobacteriaceae stronger than the first and second generation cephalosporins. 33 strains of Pseudomonas aeruginosa fluoroquinolone antibiotics (norfloxacin) has not been found resistant strains.