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再生障碍性贫血(简称再障)是不同病因、通过不同机制引起的骨髓造血功能衰竭综合症。近年对其免疫发病机理进行了广泛的研究,现就近期有关资料作一复习。一、骨髓移植中出现的现象1980年有人对22例再障采用同卵挛生子骨髓移植,公一半病例成功,失败病例中有6例并用环磷酰胺(Cy)后作第2次移植才获成功。说明并非所有再障单纯由于缺乏正常造血干细胞,cy的作用可能消除了对正常干细胞的免疫抑制。有少数同种移植失败病例,虽供体细胞消失,但出现自身骨髓的重建,这可能与移植前使用cy进行免疫抑制有关。
Aplastic anemia (referred to as aplastic anemia) is a different etiology, caused by different mechanisms of bone marrow hematopoietic failure syndrome. In recent years, its mechanism of immune pathogenesis conducted a wide range of research, is the recent data for a review. First, the phenomenon of bone marrow transplantation in 1980 was 22 cases of aplastic anemia with identical twin bone marrow transplantation, the public half of the cases were successful, six cases of failure and cyclophosphamide (Cy) after the second transplant was obtained success. This shows that not all aplastic anemia simply due to the lack of normal hematopoietic stem cells, the role of cy may eliminate the immune suppression of normal stem cells. A small number of cases of allograft failure, although for the disappearance of somatic cells, but the reconstruction of their own bone marrow, which may be related to cytoplasmic immunosuppression before transplantation.