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在商品制剂中对醋氨酚和咖啡因一起使用。USPⅩⅩⅡ版用HPLC法测定这些药品和乙酰水杨酸。因它们的UV吸收峰重叠,所以不能用直接UV吸收法测定。本文介绍用一级微分UV法测定片剂中的醋氨酚和咖啡因。将其测定结果同法定的HPLC法进行比较。本法包括从片剂中用水抽出药物,过滤,适当稀释,醋氨酚与咖啡因测定分别在216.2和205.4nm零交点波长。由dA/dλ(以D表示)值对0.3～6.0μg/ml浓度范围内的药物相应浓度制图。计
Acetaminophen and caffeine are used together in commercial preparations. USP XXII edition HPLC determination of these drugs and acetylsalicylic acid. Because of their overlapping UV absorption peaks, they can not be measured by direct UV absorption. This article describes the determination of acetaminophen and caffeine in tablets using the first-order differential UV method. The results of its determination with the statutory HPLC method for comparison. This method includes extracting the drug from the tablets using water, filtering and diluting. The acetaminophen and caffeine are measured at zero crossings of 216.2 and 205.4 nm, respectively. The corresponding concentration of drug in the range of 0.3-6.0 μg / ml was plotted from the dA / dλ (expressed as D) values. meter