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自1944年Waksman发现链霉素以来,至今已有100余个氨基糖苷类抗生素问世。然而其中大部分的抗生素均含有1,3-二氨基环醇的基本结构。从化学结构来分,具有此基本骨架的抗生素又可分为三类,即含链霉胍(1)结构的链霉素、含放线胺(2)的奇放线菌素和含2-去氧链霉胺(3)的卡那霉素、新霉素,核糖霉素等。随着新抗生素不断应用于临床,以致细菌对抗生素的耐药性也就日趋严重。1967年,梅泽浜夫等学者从卡那霉素与耐药菌作用后的产物中分离到了6′-N-乙酰卡那霉素,于是可知此耐药菌中含有
Since the discovery of streptomycin by Waksman in 1944, more than 100 aminoglycoside antibiotics have been available to date. However, most of these antibiotics contain the basic structure of 1,3-diaminocyclol. From the chemical structure, the antibiotics with this basic skeleton can be further divided into three categories: Streptomycin containing Streptomycin (1) structure, Actinomycin containing Actinomycin (2) and Actinomycin containing 2- Kanamycin, neomycin, ribomycin and the like for deoxystreptamine (3). As new antibiotics continue to be used clinically, bacterial resistance to antibiotics has become increasingly serious. In 1967, Mizuho Hamamatsu and other scholars from the kanamycin and drug-resistant bacteria isolated after 6’-N-acetyl-kanamycin, we can see that the resistant bacteria contain