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目的探讨机械通气在肠道病毒71型(EV71)感染危重症手足口病患儿救治中的应用效果及推广价值。方法采用随机抽样方法抽取EV71感染危重症手足口病患儿37例,所有患儿均在常规治疗基础上行经鼻气管插管机械通气,观察患儿机械通气前后体温(T)、呼吸(RR)、心率(HR)、血压(BP)、及血氧饱和度(SpO2)、血气分析氧分压(PaO2)、二氧化碳分压(PaCO2)变化情况,并进行自身前后对照。结果本组患儿死亡4例(10.81%),其余均治愈或好转出院;机械通气后患儿T、RR、HR、BP、SpO2、PaO2、PaCO2等指标均较机械通气前有明显改善(P<0.05)。结论 EV71感染危重症手足口病患儿行机械通气治疗可有效改善患者呼吸、心率等,维护各重要器官功能,对于患儿的救治有要的意义。
Objective To investigate the effect of mechanical ventilation on the treatment of critically ill hand-foot-mouth disease in children with enterovirus 71 (EV71) infection. Methods Thirty-seven children with EV71 were enrolled in this study. All children underwent routine mechanical ventilation through nasotracheal intubation. The changes of body temperature (T), respiration (RR) , Heart rate (HR), blood pressure (BP) and blood oxygen saturation (SpO2), blood gas analysis of PaO2, PaCO2 changes, and their own before and after the control. Results The death rate in 4 children (10.81%) in this group was cured or better than that in the control group after mechanical ventilation. The indexes of T, RR, HR, BP, SpO2, PaO2 and PaCO2 in children after mechanical ventilation were significantly improved <0.05). Conclusions The treatment of EV71 with hand-foot-mouth disease in critically ill patients with mechanical and hand-foot-mouth disease can effectively improve the respiratory and heart rate of patients, maintain the function of various vital organs, and have significance for the treatment of children.