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目的 分析总结儿童髓母细胞瘤临床特点及其治疗效果。方法 45例经手术后病理证实的儿童髓母细胞瘤进行回顾性研究 ,对其诊断、手术治疗和术后放射治疗的结果进行分析 ,并结合文献进行讨论。结果 肿瘤全切除及近全切除 32例 ,大部分切除 8例 ,部分切除 5例。手术死亡率 6 %。术后均行放射治疗。随访到 30例 ,发生中枢神经系统种植转移 4例 ,复发 6例 ,随访到 5年存活率为 5 3.3%。结论 显微镜下全切除肿瘤组织 ,解除导水管梗阻 ,术后予以全脑加全脊髓段放射治疗 ,可有效的降低复发转移率 ,显著延长生存期
Objective To analyze and summarize the clinical characteristics of children with medulloblastoma and its therapeutic effect. Methods A retrospective study of 45 children with medulloblastoma confirmed by pathology was performed. The diagnosis, surgical treatment and postoperative radiotherapy results were analyzed and discussed in the literature. Results Totally 32 cases were resected with total resection and nearly total resection, 8 cases were mostly resected and 5 cases were partially resected. Surgical mortality rate 6%. All patients underwent radiotherapy. Follow-up to 30 cases occurred in 4 cases of central nervous system implant metastasis, 6 cases of recurrence, 5-year follow-up survival rate of 5 3.3%. Conclusions Microscopically resection of tumor tissue, removal of aqueduct obstruction, postoperative whole brain plus whole spinal cord radiotherapy, can effectively reduce the recurrence and metastasis rate, significantly prolong survival