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目的探讨米非司酮治疗围绝经期功能性子宫出血的临床效果。方法回顾性分析我院诊治的45例围绝经期功能性子宫出血患者资料，均给予米非司酮15 mg口服，1次/d，连续口服3个月为1个疗程，观察治疗效果及药物副作用。结果经过治疗后45例患者中37例出现药物性闭经，5例恢复正常月经，3例月经量较之前明显减少。患者贫血症状改善明显，B超检查子宫内膜厚度较治疗前明显改善，<0.05。结论米非司酮治疗围绝经期功能性子宫出血疗效确切，副作用少，值得进一步推广应用。“,”Objective To investigate mifepristone treatment the clinical effect of perimenopausal dysfunctional uterine bleeding.Methods Retrospective analysis of diagnosis and treatment of 45 patients with perimenopausal dysfunctional uterine bleeding,15 mg were given mifepristone orally,1 times a day,continuous oral 3 months for one period of treatment,to observe the treatment effect and drug side effects.Results After treatment of 45 cases of 37 cases with drug sex amenorrhoea,5 cases of normal menstruation,3 cases of menstrual quantity decreased significantly than before. Anemia in patients with symptoms improved obviously,B ultrasonic examination was obviously improved,the thickness of the lining ( <0.05). Conclusion mifepristone treatment of perimenopausal dysfunctional uterine bleeding curative effect,less side effects,worthy of further popularization and application.