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目的:探讨DC-CIK细胞输注对急性白血病患者血清IL-6、TNF-α及血清微量蛋白水平影响研究及临床疗效。方法:选取前来我院就诊的已确诊的处于CR期的急性白血病患者68例,按照随机分配法分为对照组和治疗组,每组34例。对照组采用DA化疗方案进行巩固治疗;治疗组在对照组基础上给予DC-CIK细胞输注治疗。观察记录治疗前后两组患者血清IL-6、TNF-α、VEGF、IL-12、LDH、IFN-γ水平的变化,对两组患者临床疗效及5年后生存率情况进行系统比较。结果:治疗组在总有效率及5年生存率方面优于对照组(P<0.05);治疗后两组患者血清IL-6、TNF-α、VEGF、LDH水平均降低,血清IL-12、IFN-γ水平升高(P<0.05);治疗后,治疗组患者血清IL-6、TNF-α、VEGF、LDH水平低于对照组,血清IL-12、IFN-γ水平高于对照组(P<0.05)。结论:DC-CIK细胞输注疗法的运用能有效提高急性白血病患者治疗疗效,推测其机制与血清IL-6、TNF-α、VEGF、LDH水平的降低,及血清IL-12、IFN-γ水平的升高有关。
Objective: To investigate the effect of DC-CIK infusion on serum IL-6, TNF-α and serum trace protein levels in patients with acute leukemia and its clinical efficacy. Methods: Sixty-eight patients with confirmed acute leukemia who were diagnosed in our hospital were selected and randomly divided into control group and treatment group with 34 cases in each group. The control group was treated with DA chemotherapy. The treatment group was given DC-CIK cell infusion therapy on the basis of the control group. The changes of serum IL-6, TNF-α, VEGF, IL-12, LDH and IFN-γ in two groups were observed before and after treatment. The clinical efficacy and the survival rate after 5 years were compared systematically. Results: The total effective rate and 5-year survival rate of the treatment group were better than those of the control group (P <0.05). The levels of IL-6, TNF-α, VEGF and LDH in the two groups were decreased after treatment, (P <0.05). After treatment, the levels of IL-6, TNF-α, VEGF and LDH in the treatment group were lower than those in the control group, and the levels of serum IL-12 and IFN-γ in the treatment group were higher than those in the control group P <0.05). Conclusion: The application of DC-CIK cell infusion therapy can effectively improve the curative effect of patients with acute leukemia. It is hypothesized that its mechanism and the decrease of serum IL-6, TNF-α, VEGF, LDH levels and serum IL-12, IFN- Related to the increase.