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目的:探究CODP合并PIF患者血清炎症因子与肺功能的变化趋势。方法:选取2013年1月-2014年1月来我院就诊的慢性阻塞性肺病患者59例为研究对象,依照其并发PIF情况,分成一组(COPD),二组(CODP合并PIF)。对比两组患者肺部功能与血液炎症因子与PIF评分情况。结果:和一组相比,二组患者肺部功能较差,且吸烟指数与年龄明显比一组高,P<0.05.一组患者VEGF水平无统计学意义存在,IGF-1,TGF-β1与MMP-9存在统计学意义,P<0.05.一组患者用力肺活量,肺一氧化氮弥散量明显比二组高,(P=0.018);一组FEV/FVC指标明显比二组低(P=0.015);一组的RV/TLC明显高于二组(P=0.017);一组患者TLC%pre明显比二组高,(P<0.01)。结论:慢性阻塞性肺病并发肺间质纤维化会加重患者肺功能受损程度,IGF-1,TGF-β1与MMP-9全面参与了该过程。
Objective: To explore the change trend of serum inflammatory factors and lung function in patients with CODP combined with PIF. Methods: Fifty-nine patients with chronic obstructive pulmonary disease (COPD) admitted to our hospital from January 2013 to January 2014 were enrolled in the study. Patients were divided into two groups according to their concurrent PIF (COPD) and two groups (CODP combined with PIF). The lung function, blood inflammatory factors and PIF score were compared between the two groups. Results: Compared with one group, the pulmonary function of the two groups was poor and the smoking index and age were significantly higher than those of the other groups (P <0.05). There was no significant difference in VEGF levels between the two groups. IGF-1, TGF- (P = 0.018). The FEV / FVC index of one group was significantly lower than that of the second group (P = 0.018) = 0.015). The RV / TLC of one group was significantly higher than that of the second group (P = 0.017). The TLC% pre of one group was significantly higher than that of the second group (P <0.01). Conclusion: Pulmonary interstitial fibrosis with chronic obstructive pulmonary disease may aggravate pulmonary function impairment, and IGF-1, TGF-β1 and MMP-9 are fully involved in this process.