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目的 探讨ePTFE套管对犬移植静脉动脉化的影响.方法 36只健康犬随机分为2组,对照组移植静脉不加ePTFE套管,实验组移植静脉加ePTFE套管.采用同侧自体颈外静脉重建颈总动脉,术后2,6,10周处死动物,分离移植静脉,灌注固定.将移植静脉从中间剪断,近心端段靠近吻合口为a段,中间为b段,每隔3 mm横切a,b段,观察管壁增厚情况并测量壁厚.结果 对照组a段外侧壁厚度基础值为(0.46±0.09)mm,2,6,10周显著或极显著增厚,分别为(0.64 ± 0.06),(2.20±0.51),(3.23±0.38)mm;b段内侧壁厚度基础值为(0.46±0.09)mm,2,6,8周也显著或极显著增厚,分别为(0.59±0.05),(2.46±0.41),(2.Ol±0.11)mm.实验组a段外侧壁厚度基础值为(0.41±0.09)mm,6,10周显著或极显著增厚,分别为(0.75±0.22),(1.31±0.21)mm;b段内侧壁厚度基础值为(0.41±0.09)mm,6,10周极显著增厚,分别为(0.70 ± 0.04),(1.24±0.28)mm.与对照组相比,实验组除2周管壁增厚显著减缓外,6,10周均极显著减缓(P＜0.01).结论 移植静脉加ePTFE套管能减缓移植静脉的动脉化进程.“,”Objective To investigate the effects of ePTFE cuff on arterialization of vein after bypass surgery in dogs. Methods Thirty-six healthy dogs were randomly divided into 2 groups ( n = 18 in each group). The implanted veins in experimental group were enclosed by ePTFE, and that of the control group were not enclosed. Common carotid artery was reconstructed with ipsilateral external jugular vein. Animals were sacrificed at 2, 6 and 10w postoperatively, respectively. The vein graft was separated and using pressure perfused by formalin. The explanted vein was cut at the middle, then the proximal segment was divided into two segments, the segment near the anastomosis was as “a” segment, the other was “ b” segment. Segments a and b were sliced into 3 mm sections, respectively. Thickness of the vascular wall was analyzed and measured. Results In control group, basic value of lateral wall thickness of the a segment was (0. 46 ± 0.09) mm, and it increased to (0. 64 ±0.06) ,( 2.20 ±0.51 ),( 3.23±0. 3 8 ) mm, respectively, at 2 , 6 and 10w. Basic value of medial wall thickness of the b segment was ( 0. 46 ± 0. 09 ) mm, whichincreased to( 0. 59 ±0.05) , ( 2. 46 ±0. 41) , ( 2. 01 ±0. 11) mm, respectively at 2 , 6 and 10w. In experimental group, basic value of the lateral wall thickness of the a segment was (0.41 ±0.09) mm, and the value was (0. 75 ± 0. 22 ) , ( 1. 31 ± 0. 21 ) mm, respectively, at 6 and 10w. Basic value of the medial wall thickness of the b segment was (0.41 ± 0. 09 ) mm, which was ( 0. 70 ± 0. 04 ) , ( 1. 24 ± 0.28) mm, respectively, at 6 and lOw. Compared with the control group, the vessel wall thickness in experimental group was decreased significantly ( P ＜ 0. 01 ) . Conclusions ePTFE cuff can retard the arterialization process of implanted vein.