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多发性骨髓瘤(MM)仍是一种不能治愈的血液系统肿瘤。在MM的发病过程中,除了基因染色体的突变,MM瘤细胞与骨髓微环境的交流也扮演了极其重要的角色。骨髓微环境里各种成分能通过多条信号转导通路的异常活化从而促进MM瘤细胞的生存、增殖、迁移、耐药。这些年来,研究MM与骨髓微环境的关系,使用靶向药物针对性地治疗各条异常活化的信号通路已成为治疗MM的热点。弄清MM在骨髓中的发病机制,提高靶向治疗的针对性,增强药物对MM细胞的毒性,防止耐药,改善患者的预后已成为今后研究的热点课题。
Multiple myeloma (MM) is still an incurable hematological tumor. During the pathogenesis of MM, in addition to the mutation of the genetic chromosome, the communication between MM tumor cells and the bone marrow micro-environment also plays an extremely important role. Various components in the bone marrow microenvironment can activate, activate, proliferate, and mimic the MM tumor cells through abnormal activation of multiple signal transduction pathways. Over the years, the study of the relationship between MM and bone marrow microenvironment, the use of targeted drugs for the targeted treatment of various abnormal activation of the signal path has become a hot spot for the treatment of MM. To clarify the pathogenesis of MM in the bone marrow to improve the targeting of targeted therapy to enhance the toxicity of drugs on MM cells to prevent drug resistance and improve the prognosis of patients has become a hot topic of future research.