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探讨肝脏移植治疗终末期肝功能衰竭的疗效。方法１９９１年１０月～１９９５年７月，对２３例病人做了２４次原位肝移植，其中１７例成人，６例儿童。平均年龄２９岁。２３例接受移植的病人中所涉及的肝脏疾病有胆道闭锁５例，Ａｌａｇｉｌｅ综合征１例，原发性胆汁性肝硬化２例，隐源性肝硬化２例，酒精性肝硬化４例，Ｗｉｌｓｏｎ病１例，暴发性肝衰竭３例，多囊肝２例，继发性胆汁性肝硬化１例，乙型肝炎肝硬化１例和肝细胞性肝癌合并自身免疫性肝炎１例。１例儿科病人在移植后染上不明原因的肝炎而需进行第２次移植。１７例肝脏来源于脑死亡病人供者，７例为病人家属所提供。结果移植肝脏总存活率为８８％，病人存活率为９２％。２例死亡，其中１例病人发生原发性移植肝无功能，并在移植后３９天死于颅内出血；另１例病人死于移植肝严重排斥，并对类固醇和ＯＫＴ３的治疗无效。其余病人的肝脏功能良好。结论肝脏移植对于终末期肝功衰竭病人是唯一能挽救其生命的方法。肝脏移植的最大限制是缺乏供者，因此，提高社会大众对于器官捐赠的认识十分重要。
To investigate the efficacy of liver transplantation in the treatment of end-stage liver failure. Methods From October 1991 to July 1995, 24 patients underwent orthotopic liver transplantation in 23 patients, 17 adults and 6 children. The average age is 29 years old. Among the 23 patients who underwent transplantation, there were 5 cases of biliary atresia, 1 case of Alagile’s syndrome, 2 cases of primary biliary cirrhosis, 2 cases of cryptogenic cirrhosis, 4 cases of alcoholic cirrhosis, Wilson’s disease 1 case of disease, 3 cases of fulminant hepatic failure, 2 cases of polycystic liver disease, 1 case of secondary biliary cirrhosis, 1 case of hepatitis B cirrhosis and 1 case of hepatocellular carcinoma with autoimmune hepatitis. One pediatric patient had a second transplant after being infected with unexplained hepatitis. Seventeen patients were from brain-dead patients and seven were provided by their families. Results The total liver graft survival rate was 88%, the patient survival rate was 92%. Two patients died. One patient developed no functional liver graft and died of intracranial hemorrhage 39 days after transplantation. The other patient died of severe graft rejection and was refractory to steroid and OKT3 treatment. The rest of the patients had good liver function. Conclusion Liver transplantation is the only way to save lives in patients with end-stage liver failure. The biggest limitation of liver transplantation is the lack of donors. Therefore, it is very important to raise public awareness of organ donation.