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IL-13是新近发现的一种新的细胞因子。由Th2细胞产生。人IL-13(hIL-13)的分子量为17kD(糖基化)和12.4kD(非糖基化);鼠IL-13(mIL-13)的分子量为14k ;二者的氨基酸序列同源性为58％。hIL-13和mIL-13的基因定位于人第5号染色体和鼠第11号染色体上,并与IL-4基因紧密连锁,二者的cDNA同源性为66%。重组IL-13(γIL-13)具有多种生物学活性包括刺激前髓样细胞增殖;诱导单核细胞表达MHCⅡ类抗原和CD23,促进B细胞增殖、分化和分泌Ig,抑制炎症因子的产生和HIV-1的复制,抗肿瘤等。对其深入研究将有助于认识IL-13在炎症反应的发生和发展以及调节免疫应答方面的作用,并为其临床应用的可能性提供理论依据。
IL-13 is a newly discovered new cytokine. Produced by Th2 cells. The molecular weight of human IL-13 (hIL-13) was 17 kD (glycosylated) and 12.4 kD (non-glycosylated); the molecular weight of murine IL-13 58%. The genes of hIL-13 and mIL-13 are located on human chromosome 5 and mouse chromosome 11, and are closely linked to the IL-4 gene. The two genes have a homology of 66%. Recombinant IL-13 (γIL-13) has a variety of biological activities including stimulation of pre-myeloid cell proliferation; induction of monocytes expressing MHC class II antigens and CD23; promotion of B cell proliferation, differentiation and secretion of Ig; inhibition of inflammatory cytokine production; HIV-1 replication, anti-tumor and so on. The in-depth study will help to understand the role of IL-13 in the occurrence and development of inflammatory response and the regulation of immune response, and provide a theoretical basis for its clinical application.