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尿毒症病人体液中有各种各样物质积聚。简单的物质如水、H~+、Na~+、K~+和磷酸盐,在体内过多潴留都可引起中毒;但水、酸碱平衡及矿物质代谢即使没有明显异常也可发生尿毒症症状,说明在尿毒症时还有尿毒症毒素作用的其它物质聚积。尿毒症时甲状旁腺素过多,至少与引起尿毒症骨营养不良有部分关系。但它的过多并非排泄受限,而是继发于钙、磷酸盐、维生素D代谢的改变而分泌增加——此是Bricker的一个假设。他们证明在严重肾衰时,利钠因子或激素,由于容量扩张的刺激而积聚,如此等物质达中毒浓度,可抑制钠和其它物质在细胞内的主动转运。
Uremic patients accumulate a variety of substances in body fluids. Simple substances such as water, H ~ +, Na ~ +, K ~ + and phosphate, excessive retention in the body can cause poisoning; but water, acid-base balance and mineral metabolism can occur even if no obvious symptoms of uremia , Indicating the uremic toxins in the role of uremic accumulation of other substances. Uremia when parathyroid hormone is too much, at least with uremia caused by bone malnutrition, part of the relationship. But it is not too much excretion is limited, but secondary to calcium, phosphate, vitamin D metabolism and secretion increased - this is a assumption of Bricker. They demonstrated that in severe renal failure, natriuretic factors or hormones accumulate due to stimulation of capacity expansion, so that concentrations of these substances can inhibit the active transport of sodium and other substances within the cell.