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【目的】探讨甲状腺自身抗体阳性对体外受精-胚胎移植(IVF-ET)助孕治疗后妊娠流产的影响。【方法】回顾性分析2009年1月至2010年1月在中山大学附属第一医院生殖医学中心接受IVF治疗患者的资料,其中63名甲状腺抗体阳性但甲状腺功能正常者列入研究组,359名因单纯输卵管阻塞因素行IVF治疗者列入阴性对照组。【结果】甲状腺自身抗体阳性的不孕患者的IVF-ET受精率、种植率、妊娠率及流产率分别为72.9%,17.5%,31.7%,52.6%,对照组的受精率、种植率、妊娠率及流产率分别为73.6%,17.1%,33.2%,26.4%,其中IVF流产率明显高于对照组,差异有统计学意义。【结论】甲状腺抗体阳性患者行IVF-ET治疗后妊娠流产率明显增高,IVF治疗前和治疗过程中调节甲状腺自身免疫功能可能有一定的临床价值。
【Objective】 To investigate the influence of thyroid autoantibodies on pregnancy induced abortion after IVF-ET assisted pregnancy. 【Methods】 A retrospective analysis of January 2009 to January 2010 at the First Affiliated Hospital of Sun Yat-sen Reproductive Medicine Center for IVF treatment of patients, of which 63 were thyroid antibody positive thyroid function were included in the study group, 359 IVF treatment due to simple tubal obstruction included in the negative control group. 【Results】 The rate of IVF-ET fertilization, implantation rate, pregnancy rate and abortion rate were 72.9%, 17.5%, 31.7% and 52.6% respectively in IVF-positive infertile patients. The fertilization rate, implantation rate, pregnancy rate The rates of abortion and abortion were 73.6%, 17.1%, 33.2% and 26.4%, respectively. The IVF abortion rate was significantly higher than that of the control group, the difference was statistically significant. 【Conclusions】 The abortion rate of pregnant women with thyroid antibody positive after IVF-ET treatment is significantly higher. It may be of clinical value to regulate thyroid autoimmune function before and during IVF treatment.