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目的探讨诱导化疗后同步放化疗治疗老年局限期小细胞肺癌(LSCLC)的临床效果。方法选择2008年6月—2013年9月收治的LSCLC患者99例,按治疗方法分为研究组48例和对照组51例,2组均诱导化疗2个周期后,研究组行同步放化疗治疗,对照组行单纯化疗。观察2组临床效果及毒性作用发生情况。结果研究组完全缓解率和总有效率高于对照组(P<0.05)。2组毒性作用发生率比较差异无统计学意义(P>0.05)。研究组2、3年生存率高于对照组(P<0.05)。结论诱导化疗2个周期后进行同步放化疗对老年LSCLC具有较好的疗效,无严重毒性作用。
Objective To investigate the clinical effect of concurrent chemoradiotherapy after chemotherapy for the treatment of elderly patients with small cell lung cancer (LSCLC). Methods Ninety-nine patients with LSCLC admitted from June 2008 to September 2013 were divided into study group (48 cases) and control group (51 cases) according to the method of treatment. After two cycles of chemotherapy induction in both groups, the study group received concurrent chemoradiotherapy The control group received chemotherapy alone. The clinical effects and the toxic effects of the two groups were observed. Results The complete remission rate and total effective rate of the study group were higher than those of the control group (P <0.05). There was no significant difference in the incidence of toxic effects between the two groups (P> 0.05). The 2-year and 3-year survival rates of the study group were higher than those of the control group (P <0.05). Conclusions Chemotherapy and chemoradiotherapy after two cycles of induction chemotherapy have good curative effect on elderly patients with LSCLC without serious toxic effects.