论文部分内容阅读
研究对象为12例稳定型劳力性心绞痛病人,研究前除舌下含服硝酸甘油外停用一切抗心绞痛药。先双盲随机口服单剂卡维地洛(carvedilol)25或50 mg,或安慰剂,然后单盲口服单剂阿替洛尔50 mg,每次给药均相隔48小时。每次给药前和给药后30分钟分别测血压和心率,给药后2小时分别进行运动试验。结果:卡维地洛50mg和阿替洛尔50mg能使静息心率较安慰剂每分钟分别降低11次和12次,平均运动时间较安慰剂分别缩短24%和34%,运动至心绞痛时间较安慰
Participants were 12 stable patients with angina pectoris. Before study, all antianginal drugs were stopped except sublingual nitroglycerin. A double-blind randomized single-dose oral carvedilol 25 or 50 mg, or placebo, followed by a single blind oral single-dose atenolol 50 mg, was administered 48 hours apart. Blood pressure and heart rate were measured before administration and 30 minutes after administration, and exercise tests were performed two hours after administration. RESULTS: Carvedilol 50 mg and atenolol 50 mg reduced the resting heart rate 11 and 12 times per minute, respectively, with an average exercise time of 24% and 34% shorter than placebo, respectively. The duration of exercise to angina pectoris was longer comfort