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为确定缓解期急性淋巴细胞白血病(ALL)经骨髓移植(BMT)后不作中枢神经系统(CNS)预防性治疗的患者CNS复发的危险性,作者系统回顾92例ALL和晚期何杰金病(NHL),其中66例作异基因骨髓移植(allo-BMT:ALL 61例,NHL 5例),26例作自体骨髓移植(auto-BMT:ALL 21例,NHL5例).BMT前有22例CNS受累,其中allo-BMT组15例,auto-BMT组7例.15例在初次完全缓解(CR),7例在以后CR时进行移植.15例初次CR后BMT者移植前进行选择性CNS治疗,鞘内注射(ITC)或/和颅照射(CRT).
To determine the risk of CNS recurrence in patients with prophylactic Acute Lymphoblastic Leukemia (ALL) who did not undergo prophylactic treatment of the Central Nervous System (CNS) following a bone marrow transplant (BMT), we systematically reviewed 92 ALL and advanced Hodgkin’s disease ), Of which 66 were allogeneic bone marrow transplantation (allo-BMT: ALL 61, NHL 5), 26 were autologous bone marrow transplantation (auto-BMT: ALL 21, NHL 5) , Of which 15 were in allo-BMT group and 7 in auto-BMT group.There were 15 cases of complete remission (CR) in initial stage and 7 cases of CR in later stage.All of the 15 patients with primary BMT after CR were treated with selective CNS before transplantation, Intrathecal (ITC) or / and cranial irradiation (CRT).