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目的探讨磁敏感加权成像(susceptibility weighted imaging sequence,SWI)检测脑微出血(cerebral microb-leeds,CMBs)的优势,并分析CMBs的相关临床危险因素及其临床意义。资料与方法经磁共振常规序列及SWI序列检测CMBs,搜集189例患者,其中CMBs阳性者79例,且经蒙特利尔认知评估(MoCA)量表及简易智能状态检查量表(MMSE)评价CMBs阳性患者的认知功能情况。结果 SWI对CMBs的病灶检出数较常规序列明显增多;CMBs主要分布在颞叶及基底节区,高血压、糖尿病、白质严重程度、急性梗死及腔隙性梗死与CMBs的存在与否有显著性差异(P<0.01),且CMBs阳性患者的MoCA量表总分(r=-0.86,P<0.00)及MMSE总分(r=-0.79,P<0.00)与CMBs总数呈明显负相关。结论 SWI较常规序列能更好地显示CMBs,具有重要的临床价值;高血压、糖尿病、白质改变、急性梗死及腔隙性梗死与CMBs的存在有密切相关性,大量CMBs与患者认知功能受损密切相关。
Objective To investigate the advantages of magnetic susceptibility weighted imaging sequence (SWI) in detecting cerebral microbes (CMBs) and to analyze the clinical risk factors and their clinical significance of CMBs. Materials and Methods CMBs were detected by routine MRI sequences and SWI sequences. A total of 189 patients were collected, of which 79 were positive for CMBs. The CMBs positive were assessed by the MoCA scale and the MMSE (Simple Mental Status Examination Scale) Patient’s cognitive function. Results The number of lesions detected by SWI in CMBs was significantly higher than that in normal controls. CMBs were mainly located in temporal lobe and basal ganglia. There was significant difference in the severity of hypertension, diabetes, white matter, acute infarction, lacunar infarction and CMBs (P <0.01). The total MoCA scale score (r = -0.86, P <0.00) and MMSE score (r = -0.79, P <0.00) in CMBs positive patients were negatively correlated with the total number of CMBs. Conclusions SWI can display CMBs better than conventional sequence and has important clinical value. There is a close correlation between hypertension, diabetes mellitus, white matter changes, acute infarction and lacunar infarction and the presence of CMBs. CMBs and cognitive functions Loss is closely related.