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目的:分析玉林市2006~2008年围产儿出生缺陷发生情况,为制定和采取预防措施提供科学决策依据。方法:调查对象为监测点内孕28周至产后1周的围产儿,对围产儿出生缺陷监测进行回顾性分析。结果:2006~2008年围产儿出生缺陷率8.30‰(2 379/286 722),其中2006年出生缺陷率为8.06‰(688/85 339),2007年出生缺陷率为8.79‰(813/92 480),2008年出生缺陷率为8.06‰(878/108 903),经统计学处理,差异无统计学意义(P>0.05)。首位为胎儿水肿综合征占21.98%,依次为唇裂与腭裂占16.35%,多指(趾)占11.01%,四肢短缩占5.17%,脑积水占5.13%,先天性心脏病占3.28%,神经管缺陷占3.57%,唐氏综合征占1.26%。该院围生儿出生缺陷的转归,活产占43.85%,治疗性引产占39.75%,死胎占16.39%。结论:减少出生缺陷的工作重点在预防,应加强优生知识的宣传,提高产前检查,产前诊断技术,降低有缺陷胎儿的活产率,降低出生缺陷的出生率,提高出生人口素质。
OBJECTIVE: To analyze the incidence of birth defects in perinatal children from 2006 to 2008 in Yulin, and to provide a scientific basis for decision-making and preventive measures. Methods: The object of investigation was to monitor the perinatal children within 28 weeks of pregnancy and 1 week after delivery, and to analyze the monitoring of birth defects in perinatal children. Results: The birth defect rate of perinatal children was 8.30 ‰ (2 379/286 722) from 2006 to 2008, of which the birth defect rate was 8.06 ‰ (688/85 339) in 2006. The birth defect rate in 2007 was 8.79 ‰ (813/92 480 ). The birth defect rate in 2008 was 8.06 ‰ (878/108 903). There was no significant difference between the two groups (P> 0.05). The first was fetal edema syndrome accounted for 21.98%, followed by cleft lip and cleft palate accounted for 16.35%, fingers (toes) accounted for 11.01%, short limbs accounted for 5.17%, hydrocephalus 5.13%, congenital heart disease accounted for 3.28% Neural tube defects accounted for 3.57%, Down Syndrome accounted for 1.26%. The hospital outcome of perinatal child birth defects, live births accounted for 43.85%, therapeutic induced abortion accounted for 39.75%, stillbirth accounted for 16.39%. Conclusion: To reduce birth defects, we should focus on prevention. We should strengthen the propaganda of prenatal knowledge, improve prenatal diagnosis and prenatal diagnosis, reduce the live birth rate of defective fetuses, reduce the birth defects of birth defects and improve the quality of birth population.