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目的探讨氧化低密度脂蛋白(OX-LDL)在冠心病动脉粥样硬化(AS)发生发展中的作用及其相关性。方法测定所有研究对象血压、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、尿素氮(BUN)、肌酐(Cr)、血糖(S)等指标,采用不连续密度梯度离心及体外LDL氧化修饰法检测稳定型心绞痛(SAP)组30例,不稳定型心绞痛(UAP)组32例,急性心肌梗死(AMI)组28例,正常对照组38例等的OX-LDL水平。结果AMI组分别与正常对照组、SAP组、UAP组比较,OX-LDL水平有显著性差别(P<0.01),SAP组和UAP组分别与正常对照组比较,OX-LDL水平无显著性差异(P>0.05),冠心病患者OX-LDL与TC、TG、LDL成正相关,与HDL成负相关。结论CHD患者OX-LDL水平可作为早期诊断心肌梗死的一个敏感指标,冠心病脂代谢异常是发生AS的重要危险因素之一。
Objective To investigate the role of oxidized low density lipoprotein (OX-LDL) in the development and progression of atherosclerosis (AS) in coronary heart disease. Methods Blood pressure, cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), blood urea nitrogen (BUN), creatinine (Cr) 30 cases of stable angina pectoris (SAP) group, 32 cases of unstable angina pectoris (UAP) group, 28 cases of acute myocardial infarction (AMI) group and 28 cases of normal control group were treated with discontinuous density gradient centrifugation and in vitro LDL oxidative modification 38 cases such as OX-LDL levels. Results Compared with normal control group, SAP group and UAP group, the level of OX-LDL in AMI group was significantly different (P <0.01). There was no significant difference in OX-LDL level between SAP group and UAP group (P> 0.05). OX-LDL in patients with coronary heart disease was positively correlated with TC, TG and LDL, and negatively correlated with HDL. Conclusion The level of OX-LDL in patients with CHD can be used as a sensitive indicator of early diagnosis of myocardial infarction. The abnormal lipid metabolism of coronary heart disease is one of the important risk factors of AS.