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目的研究急性脑血管病(脑梗死和脑出血)患者的血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物(PAI-1)的活性变化及临床意义。方法采用酶联免疫吸附法测定67例急性脑梗死和53例脑出血患者的t-PA和PAI-1的活性,并计算P/t值,与50例正常对照组进行比较分析。结果急性脑血管病组患者急性期(7d内)血浆t-PA及PAI-1活性均升高,与正常对照组比较有显著性差异(P<0.05);脑梗死组P/t值与正常对照组比较有显著性差异(P<0.05);脑出血组P/t值与正常对照组比较无显著性差异(P>0.05)。结论脑梗死和脑出血患者急性期血浆P/t改变不同;脑梗死患者急性期P/t降低,体内处于相对纤溶亢进状态;脑出血患者P/t变化不明显,体内凝血纤溶机制相对平衡;P/t值可以更好地反映血液中的纤溶活性。
Objective To investigate the changes of plasma t-PA and PAI-1 in patients with acute cerebrovascular disease (cerebral infarction and cerebral hemorrhage) and their clinical significance. Methods The activity of t-PA and PAI-1 in 67 patients with acute cerebral infarction and 53 patients with intracerebral hemorrhage were determined by enzyme-linked immunosorbent assay. The P / t value was calculated and compared with 50 normal controls. Results The levels of plasma t-PA and PAI-1 in patients with acute cerebrovascular disease were significantly higher than those in normal controls (P <0.05) in acute phase (within 7 days) There was significant difference between the control group and the control group (P <0.05). There was no significant difference in the P / t between the cerebral hemorrhage group and the normal control group (P> 0.05). Conclusions The changes of plasma P / t in acute cerebral infarction and intracerebral hemorrhage are different. The P / t in acute phase of cerebral infarction is decreased and the body is relatively hyperfibrinolytic. The changes of P / t in cerebral hemorrhage are not obvious, and the mechanism of coagulation and fibrinolysis is relative Balance; P / t value can better reflect the fibrinolytic activity in the blood.