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目的:研究ER、PR、Ki-67的表达与子宫肌瘤的关系,分析ER、PR、Ki-67在子宫肌瘤中表达的相互关系,进一步研究ER、PR、Ki-67的表达与不同直径、数量、部位的子宫肌瘤之间的关系,探讨ER、PR、Ki-67在子宫平滑肌瘤发生、发展中的作用。方法:应用免疫组化染色EnVision二步法测定61例子宫肌瘤和30例相应正常子宫肌层组织的雌激素受体(ER)、孕激素受体(PR)和增殖细胞核抗原(Ki-67),应用SPSS 17.0统计分析软件对数据进行统计及相关性分析。结果:子宫肌瘤组织中PR的含量较相应正常子宫肌层组织高,差异有统计学意义(P<0.000 5);直径>5 cm的肌瘤组内ER、PR的含量均高于直径≤5 cm内的肌瘤组(P<0.05)。结论:子宫肌瘤的发生发展与ER、PR的表达有关,尚不能认为子宫肌瘤与Ki-67的表达有关及子宫肌瘤中ER、PR、Ki-67的表达之间存在相互关系。
OBJECTIVE: To study the relationship between the expression of ER, PR and Ki-67 and uterine leiomyoma, to analyze the relationship between the expression of ER, PR and Ki-67 in uterine leiomyoma and to further study the expression of ER, PR and Ki-67 Diameter, number, location of uterine fibroids, explore the role of ER, PR, Ki-67 in the occurrence and development of uterine leiomyomas. Methods: The expressions of estrogen receptor (ER), progesterone receptor (PR) and proliferating cell nuclear antigen (Ki-67) in 61 cases of uterine myoma and 30 cases of corresponding normal myometrium were detected by EnVision immunohistochemical staining. ), The application of SPSS 17.0 statistical analysis software for statistical and correlation analysis of the data. Results: The content of PR in uterine fibroids was higher than that in corresponding normal myometrium (P <0.0005), and the contents of ER and PR in fibroids> 5 cm were higher than those in patients with diameter ≤ 5 cm within the fibroid group (P <0.05). Conclusions: The occurrence and development of uterine fibroids are related to the expression of ER and PR. However, it is not yet known that there is a correlation between the expression of Ki-67 and the expression of ER, PR and Ki-67 in uterine leiomyoma.