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目前根除H.pylori感染的一线治疗方案很多,最常用的方法为:铋剂或质子泵抑制剂(PPI)合并两种抗生素组成的三联疗法或铋剂+PPI合并两种抗生素组成的四联疗法。然而随着H.pylori对抗生素耐药性的产生,这些方案可能会在疗效上受到不同程度的影响。选择疗效高、不良反应少、较少产生耐药性且病人易于接受的H.pylori根除治疗方案是目前迫切需要解决的问题。然而直到目前为止,直接比较上述常用治疗方案的大规模、前瞻性对照研究尚属空
Currently there are many first-line treatment options for the eradication of H.pylori infection. The most commonly used methods are: bismuth or proton pump inhibitor (PPI) triple therapy consisting of two antibiotics or bismuth and PPI combination quadruple therapy consisting of two antibiotics . With the development of antibiotic resistance of H.pylori, however, these regimens may have varying degrees of efficacy. It is an urgent problem to choose H.pylori eradication therapy with high curative effect, less adverse reactions, less resistance and patient acceptance. However, so far, large-scale, prospective, controlled studies that directly compare these common treatment regimens are still empty