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目的：了解胆囊结石患者其胆管树损伤情况。方法：收集２２例胆囊结石病例，１０例猝死尸检病例而无肝胆系统疾患者作为对照组，两者经组织学观察和定量分析。结果：胆囊结石组门管区平均面积０．０８４ｍｍ２，对照组０．１０１ｍｍ２。胆囊结石组门管区胆管数量３．１，对照组５．３。两者经统计学分析差异有显著性意义（Ｐ均＜０．０１）。胆囊结石病例大多有门管区胆管数量的减少和以变质为主的炎症。结论：胆囊结石患者分泌的异常胆汁，可引起胆管树的损伤，导致胆管数量的减少。
Objective: To understand the bile duct injury in patients with gallstone. Methods: Twenty-two cases of cholecystolithiasis, 10 cases of sudden death and autopsy were selected as the control group without hepatobiliary diseases, both of which were histologically observed and quantitatively analyzed. Results: The average size of portal area of gallstone group was 0.084mm2, while that of control group was 0.101mm2. The number of choledocholithiasis in cholecystolithiasis group 3.1 and control group 5.3. The two statistically significant differences (P <0.01). Most cases of gallstone stones have reduced the number of duct bile duct area and the deterioration of the main inflammation. Conclusion: Abnormal gallbladder secretion in patients with gallstone can cause injury to the biliary tree, resulting in a decrease in the number of bile ducts.