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目的:探讨一氧化氮(NO)和微量元素锌(Zn)在病毒性心肌炎(VMC)中的作用及临床意义。方法:采用比色法、原子吸收分光光度分析法测定42例VMC患儿及23例正常健康儿的血清NO、Zn水平。结果:急性期VMC患儿血清NO含量为(61.35±18.92)μmol/L,较对照组(23.81±5.37)μmol/L、恢复期(33.95±8.86)μmol/L患儿明显升高(P<0.01);而急性期VMC患儿血清Zn浓度为(76.81±11.05)μmol/L,较对照组(116.28±11.76)μmol/L、恢复期(89.75±9.90)μmol/L患儿降低(P<0.01);VMC患儿急性期NO与Zn呈高度负相关(P<0.05)。结论:血清NO、Zn含量变化与VMC的发生发展有关。
Objective: To investigate the role and clinical significance of nitric oxide (NO) and trace element zinc (Zn) in viral myocarditis (VMC). Methods: The levels of serum NO and Zn in 42 children with VMC and 23 normal children were determined by colorimetric method and atomic absorption spectrophotometry. Results: The serum NO level in children with acute VMC was (61.35 ± 18.92) μmol / L, which was significantly higher than that in control group (23.81 ± 5.37 μmol / L, 33.95 ± 8.86 μmol / L, P < 0.01). However, the serum level of Zn in the acute VMC patients was (76.81 ± 11.05) μmol / L, which was significantly lower than that in the control group (116.28 ± 11.76 μmol / L, 89.75 ± 9.90 μmol / L, 0.01). There was a highly negative correlation between NO and Zn in children with VMC (P <0.05). Conclusion: The changes of serum NO and Zn levels are related to the occurrence and development of VMC.