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核因子NF-κB(Nuclear factor kappa-B,NF-κB)是一种多向性的转录因子,它参与多种炎症和免疫应答相关分子基因的表达,同时也参与调控细胞的增殖和分化。它在动脉粥样硬化、关节炎、哮喘、肿瘤等疾病的发展中都起了重要的作用。炎症是多种细胞及细胞因子参与的机体防御性反应,但严重或长期的炎症则会造成机体损伤。溃疡性结肠炎(UC)是一组以慢性、周期性炎症为特征的肠道疾病,长期、反复的肠道炎症不仅影响患者生活质量,而且增加了肠道纤维化及癌变的风险,而核因子NF-κB与炎症反应关系非常密切。本文就NF-κB的作用与UC的联系作一简要综述。
Nuclear factor kappa-B (NF-κB) is a multi-directional transcription factor that participates in the expression of a variety of inflammatory and immune-related molecular genes and is also involved in the regulation of cell proliferation and differentiation. It plays an important role in the development of diseases such as atherosclerosis, arthritis, asthma and cancer. Inflammation is the body’s defensive response to a variety of cells and cytokines, but severe or long-term inflammation can cause body damage. Ulcerative colitis (UC) is a group of intestinal diseases characterized by chronic, periodic inflammation. Prolonged and repeated intestinal inflammation not only affects the quality of life of patients, but also increases the risk of intestinal fibrosis and carcinogenesis, while nuclear The factor NF-κB is closely related to the inflammatory response. In this paper, the role of NF-κB and UC for a brief review.