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目的 提高临床医师对广州管圆线虫病的认识。方法 分析 18例广州管圆线虫病所致嗜酸粒细胞性脑膜脑炎的临床特征及实验室、流行病学调查资料。结果 发病前均有生食淡水螺肉史 ,潜伏期 1- 2 5天。以头痛、躯体痛为主要表现 ,头痛剧烈而脑膜刺激征不明显。周围血象、脑脊液中嗜酸粒细胞明显增高 ,血清广州管圆线虫抗体阳性 (ELISA法 )。头颅CT正常 ,2例磁共振 (MR)检查呈斑片状异常信号 ,脑电图α波变慢。用阿苯哒唑、氟美松治疗效果好 ,预后佳。结论 广州管圆线虫病是嗜酸粒细胞性脑膜脑炎的主要病因之一
Objective To improve clinicians’ understanding of angiostrongyliasis in Guangzhou. Methods The clinical features, laboratory and epidemiological investigation data of eosinophilic meningoencephalitis in 18 cases of angiostrongychiasis were analyzed. Results Before the onset of raw freshwater snail meat history, the incubation period of 1-25 days. To headache, body pain as the main performance, severe headache and meningeal irritation is not obvious. Peripheral blood, cerebrospinal fluid eosinophilia was significantly increased, serum Acanthus angusta antibody (ELISA method). Head CT normal, 2 cases of magnetic resonance (MR) examination showed abnormal patchy signals, E wave slowed. With albendazole, dexamethasone treatment effect is good, good prognosis. Conclusion Angiostrongyliasis is one of the major causes of eosinophilic meningoencephalitis