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引言固定化酶和其它大分子已被制成许多在工业和医学上使用的长效释药体系。但是,这些体系受下列因素限制:(A)包于释药体系的物质数量受限;(B)体系的非控释性;(C)需用外科手术取出不降解骨架;(D)骨架的生物相容性差。理论上讲,采用细胞微囊化作为激素、酶和其它大分子的释药体系有一定优点,因在生物相容膜内的细胞.由于免疫隔离使副反应减少,同时使细胞分泌物的生理性释放延长。本文叙述有关藻酸盐—聚赖氨酸—藻酸盐膜包囊的胰岛、肝细胞的体内外长效性研究。材料和方法动物杂交Wistar大鼠,雄性,体重200～300g
Introduction Immobilized enzymes and other macromolecules have been made into many long-acting drug delivery systems for industrial and medical use. However, these systems are limited by: (A) the limited number of substances contained in the drug delivery system; (B) the non-controlled release of the system; (C) the non-degradable scaffolds to be surgically removed; (D) Biocompatibility is poor. In theory, the use of microencapsulation of cells as hormones, enzymes and other macromolecules release system has some advantages, due to the cells in the biocompatible membrane due to immunological isolation to reduce side effects, while the secretion of cells in the physiology Sexual release extended. This article describes the long-term in vivo and in vitro studies of islet and hepatocytes encapsulated by alginate-polylysine-alginate membranes. Materials and Methods Animal Wistar rats, male, weighing 200-300 g