【摘 要】
：
Analysis errors can occur in the desorbing process of ginkgo diterpene lactone meglumine injection (GDMI) by a conventional analysis method, due to several factors, such as easily crystallized samples, solvent volatility, time-consuming sample pre-process
【机 构】
：
Nanjing University of Traditional Chinese Medicine,Nanjing 210000,China;Jiangsu Kanion Pharmaceutica
论文部分内容阅读
Analysis errors can occur in the desorbing process of ginkgo diterpene lactone meglumine injection (GDMI) by a conventional analysis method, due to several factors, such as easily crystallized samples, solvent volatility, time-consuming sample pre-processing, fixed method, and offline analysis. Based on risk management, near-infrared (NIR) and mid-infrared (MIR) spectroscopy techniques were introduced to solve the above problems with the advantage of timely analysis and non-destructive nature towards samples. The objective of the present study was to identify the feasibility of using NIR or MIR spectroscopy techniques to increase the analysis accuracy of samples from the desorbing process of GDMI. Quantitative models of NIR and MIR were established based on partial least square method and the performances were calculated. Compared to NIR model, MIR model showed greater accuracy and applicability for the analysis of the GDMI desorbing solutions. The relative errors of the concentrations of Ginkgolide A (GA) and Ginkgolide B (GB) were 2.40％ and 2.89％, respectively, which were less than 5.00％. The research demonstrated the potential of the MIR spectroscopy technique for the rapid and non-destructive quantitative analysis of the concentrations of GA and GB.
其他文献
Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects.However, the anti-atopic dermatitis (AD) activity of BS has not been described yet.In the present study, we examined t
Herba Anoectochili is a commonly used medicinal material.However,its adulteration is a serious concern.Due to the similar morphological characteristics of Herba Anoectochili and its adulterants,traditional identification techniques often fail to distingui
The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products (AGEs) in vitro.Bioactivity-guided fractionation of
Romipeptides A and B (1 and 2),two new romidepsin derivatives,and three known compounds,chromopeptide A (3),romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No.968.Their structures were
Replacement of the native promoter of the global regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites,named dalestones A and B,whose structures were assigned by a combina
Notopterygium incisum (QH) has been used for the treatment of rheumatoid arthritis (RA),and volatile oils may be its mainly bioactive constituents.The present study was designed to analyze the volatile compounds in QH and to determine the anti-arthritic c
Astragali Radix,the root of Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge.,is widely used as a tonic decoction pieces in the clinic of traditional Chinese medicine (TCM).Astragali Radix has vario
Sophorae Flavescentis Radix (Sophora flavescens Ait.,SFR) and Sophorae Tonkinensis Radix et Rhizoma (S.tonkinensis Gapnep.,STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants,which are believed to possess similar bio
Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolatio
Catalpol, a major bioactive component from Rehmannia glutinosa, which has been used to treat diabetes. The present study was designed to elucidate the anti-diabetic effect and mechanism of action for catalpol in db/db mice. The db/db mice were randomly di