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目的 分析nm23－H1（简称nm23－H1）在胃癌分化、浸润转移中的作用及其表达的临床意义。方法 应用ABC免疫组化方法，研究46例原发性胃癌组织及其转移淋巴结nm23－H1的表达。结果 45．6％（21／46）的胃癌nm23－H1表达下降。nm23－H1的阳性表达与Borrmann分型、组织学分型无关（P＞0．05），而与肿瘤大小、胃癌浸润深度、临床病理分期、淋巴结转移密切相关（P＜0．05）。另外54．5％的分化型胃癌nm23－H1表达高于其淋巴结转移癌，而在低分化型胃癌中有53．8％。结论 nm23－H1可能对胃癌的浸润、淋巴结转移有抑制作用。
Objective To analyze the role of nm23-H1 (nm23-H1) in the differentiation, invasion and metastasis of gastric cancer and its clinical significance. Methods The expression of nm23-H1 in 46 primary gastric cancer tissues and their metastatic lymph nodes was studied by ABC immunohistochemistry. Results The expression of nm23-H1 decreased in 45.6% (21/46) gastric cancer. The positive expression of nm23-H1 was not associated with Borrmann type and histological type (P>0.05), but was closely related to tumor size, invasion depth of gastric cancer, clinical pathological stage and lymph node metastasis (P<0.05). In addition, the expression of nm23-H1 in 54.5% of differentiated gastric cancer was higher than that in metastatic lymph node metastasis and 53.8% in poorly differentiated gastric cancer. Conclusion nm23-H1 may have inhibitory effects on gastric cancer infiltration and lymph node metastasis.