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目的探讨脓毒血症儿童血清降钙素原和炎症因子的相关性,为临床治疗提供指导。方法随机选取郑州市第一人民医院2011年8月—2013年12月期间收治的脓毒血症患儿45例作为实验组,另选取同期健康儿童45例作为对照组,对两组儿童进行血常规、降钙素原(PCT)和炎症因子(TNF-α、hs-CRP、IL-10等)水平检测,并对检测结果进行分析。结果血清PCT同TNF-α、hs-CRP、IL-1β、IL-8、IL-6呈正相关关系,同IL-10呈负相关。结论脓毒血症儿童血清PCT同炎症因子之间存在明显相关性,其具体作用机制仍有待进行进一步深入研究。
Objective To investigate the correlation between serum procalcitonin and inflammatory cytokines in sepsis children and provide guidance for clinical treatment. Methods 45 cases of sepsis children admitted in First People’s Hospital of Zhengzhou City from August 2011 to December 2013 were randomly selected as experimental group and 45 healthy children in the same period as control group. Routine, procalcitonin (PCT) and inflammatory cytokines (TNF-α, hs-CRP, IL-10, etc.) levels were detected, and the test results were analyzed. Results Serum PCT was positively correlated with TNF-α, hs-CRP, IL-1β, IL-8 and IL-6, and negatively correlated with IL-10. Conclusion There is a clear correlation between serum PCT and inflammatory cytokines in sepsis children. The specific mechanism remains to be further studied.