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维生素A对人有益还是有害,已成为目前的一个重要研究课题.最近令人最大关注的焦点是,对于人,应用大剂量维生素A类似物能否导致畸胎.对于动物,维生素A的潜在致畸胎作用,业已认识达30多年之久,Cohlan报道,对Wistar大鼠,每天应用7500国际单位(IU)以上的剂量,能导致种种畸形,最常见的有露脑畸形、唇裂和腭裂,按鼠体重的剂量给人用,其剂量要大于25百万IU.Giroud等证实,缺陷的类型将根据妊娠哪一时间给药而有所不同.对小鼠,每天应用至少250IU,才能导致这些缺
Whether vitamin A is beneficial or detrimental to people has become an important research topic at present.It has been the focus of great interest recently that whether high doses of vitamin A analogues can lead to teratogenicity in humans is the potential cause of vitamin A in animals Teratogenesis, which has been recognized for more than 30 years, Cohlan reported that doses of more than 7,500 IU per day in Wistar rats can cause various deformities, most commonly deformities, cleft lip and cleft palate The dose of rat body weight is administered to humans at doses greater than 25 million IU. Giroud et al. Confirm that the type of defect will vary depending on when the pregnancy is administered. In mice, daily application of at least 250 IU results in these deficits