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目的：观察促甲状腺素释放激素（ＴＲＨ）与多巴胺（ＤＡ）伍用对高原创伤低血容量性休克大鼠的治疗作用。方法：初进高原大鼠２８只，分生理盐水对照组（８只），ＴＲＨ组（７只），ＤＡ组（６只）和ＴＲＨ与ＤＡ合用组（７只）。大鼠右侧股骨粉碎性骨折加放血（血压６．０ｋＰａ维持１小时）复制创伤低血容量性休克模型，观察ＴＲＨ（５ｍｇ／ｋｇ）、ＤＡ（１ｍｇ／ｋｇ）和ＴＲＨ与ＤＡ半量合用对创伤低血容量性休克大鼠血流动力学指标和大鼠存活时间的影响。结果：ＴＲＨ单用或与ＤＡ合用能显著提高休克大鼠的血压，改善心肌收缩向量环面积（Ｌｏ），两药单用或合用均能改善休克大鼠左心室收缩压（ＬＶＳＰ）、左心室收缩压最大变化速率（±ｄｐ／ｄｔｍａｘ）、心肌最大收缩速度（Ｖｐｍ）；ＴＲＨ单用及与ＤＡ合用可明显延长休克大鼠的存活时间，合用效果优于ＴＲＨ或ＤＡ单用效果，并显示出一定的协同作用。结论：ＴＲＨ与ＤＡ合用抗高原创伤低血容量性休克有一定的协同作用。
Objective: To observe the therapeutic effect of the combination of thyrotropin-releasing hormone (TRH) and dopamine (DA) on traumatic hemorrhagic shock in rats with plateau trauma. Methods: 28 rats were randomly divided into normal saline control group (n = 8), TRH group (n = 7), DA group (n = 6) and TRH combined with DA group (n = 7). The right traumatic fracture of the femur was transplanted with blood (6.0kPa for 1 hour) to replicate the hypovolemic shock model. The effects of TRH (5mg / kg), DA (1mg / kg) Effects of hypovolemic shock on hemodynamics and survival time in rats. Results: TRH alone or in combination with DA could significantly increase blood pressure and improve systolic vector annulus (Lo) in shock rats. Both alone or in combination, TRH could improve left ventricular systolic pressure (LVSP), left ventricular Systolic blood pressure (± dp / dtmax), myocardial maximum systolic velocity (Vpm); TRH alone and in combination with DA can significantly prolong the survival time of shock rats, combined effect is better than the effect of TRH or DA alone, and showed A certain synergy. Conclusion: TRH and DA combined anti-plateau trauma hypovolemic shock have some synergies.