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目的:通过对孕早、中、晚期妊娠妇女骨密度及血钙磷测定,观察骨代谢特点,为围产保健提供理论依据。方法:选择2012年6月~2013年6月在我院门诊产前检查的早、中、晚期孕6~41周孕妇583例正常单胎为观察对象,正常未孕健康妇女136名为对照观察不同季节体内钙含量。结果:各孕周组与对照组比较,P<0.001有显著差异。血清Ca、P的含量均位于正常值中的偏低水平,各组间无统计学差异,P>0.05,各组间的年龄、身高、体重与对照组比较无统计学差异,P>0.05。在春季怀孕组的妇女至冬季分娩时BMD丢失率为最高,分别为60%、65.5%。结论:妊娠各期骨含量明显降低,说明孕妇为了适应胎儿生长发育的需要,钙的需求量明显增加,建议妊娠早期开始应及时指导孕妇合理膳食,适时补充钙剂和维生素D等。
OBJECTIVE: To observe the bone metabolic characteristics of pregnant women in early, middle and late stages of pregnancy by measuring bone mineral density and serum calcium and phosphorus, and to provide a theoretical basis for perinatal health care. Methods: From June 2012 to June 2013, 583 normal singletons from 6 to 41 weeks old in prenatal, early, middle and late pregnancy in our hospital were selected as observation objects and 136 healthy non-pregnant healthy women as control group Calcium content in different seasons. Results: Compared with the control group, gestational weeks group, P <0.001 significant difference. There was no significant difference between the two groups (P> 0.05). There was no significant difference in age, height and weight between the two groups (P> 0.05). Women in the spring pregnancy group had the highest loss of BMD at winter delivery, at 60% and 65.5%, respectively. Conclusion: The content of bone in each stage of pregnancy is significantly reduced, indicating that pregnant women in order to adapt to the needs of fetal growth and development, the demand for calcium increased significantly, it is recommended early pregnancy should be timely guidance of a reasonable diet of pregnant women, timely replacement of calcium and vitamin D.