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目的观察左氧氟沙星联合头孢哌酮治疗肺部多重耐药杆菌感染的疗效。方法 50例患者分成两组,观察组应用左氧氟沙星与头孢哌酮,对照组给予头孢曲松,疗程结束后观察临床疗效、细菌清除率及安全性评价。结果观察组治疗有效率为92.00%,细菌清除率为86.86%,对照组有效率80.00%,细菌清除率为81.82%,两组比较差异有统计学意义(P﹤0.05)。而研究中观察组、对照组不良反应均为2例,差异无统计学意义。结论左氧氟沙星联合头孢哌酮治疗肺部多重耐药杆菌感染疗效较好,菌株清除率高,安全性佳,值得临床推广。
Objective To observe the efficacy of levofloxacin and cefoperazone in the treatment of multi-drug resistant bacilli in lungs. Methods 50 patients were divided into two groups. The observation group was given levofloxacin and cefoperazone. The control group was given ceftriaxone. The clinical efficacy, bacterial clearance rate and safety evaluation were observed after the treatment. Results The effective rate of the observation group was 92.00%, the bacterial clearance rate was 86.86%, the effective rate of the control group was 80.00% and the bacterial clearance rate was 81.82%. The difference between the two groups was statistically significant (P <0.05). In the study of observation group, the control group were 2 cases of adverse reactions, the difference was not statistically significant. Conclusion Levofloxacin combined with cefoperazone is effective in the treatment of multi-drug resistant bacilli in the lungs. It has high clearance rate and safety, which is worthy of clinical promotion.