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目的 作者对20,000多单位血液受血者进行追踪,以鉴定通过输血传播的感染。设计 对受血者进行随访调研。背景伦敦北部的22所医院。参与者 近期输血的成年患者。主要结果测定 在输血9个月后采集受血者血液标本,检测HCV、HBV、HIV和HTLV-Ⅰ型、Ⅱ型感染标志物。通过与输血前采集的血液标本进行比较来区分新近感染或输血前感染。结果9,920例患者参试。对21,923单位血液的5,579例受血者进行了追踪,但未发现输血传播感染病例。对乙型肝炎,21,043单位血液的输血传播感染范围为0(可信限范围95％,5,706例受血者输血感染风险为0～1);丙型肝炎为0/21,800单位血液(输血感染风险0～1/5,911例受血者);HIV为0/21,923单位血液(输血无感染风险为0-1/5,944例受血者);HTLV为0/21,902单位血液(输血感染风险为0-1/5,939例受血者)。3例患者在住院期间和住院之后感染了乙型肝炎,但被证明不是通过输血途径感染的。176例(3％)患者在住院之前已感染了乙型肝炎,16例(0.29％)感染了丙型肝炎,5例(0.09％)感染了HTLV。结论:在英国,目前通过输血传播的感染极少,而通过医院其它途径比输血途径更可能获得感染。在感染患者中较多的是以前获得的感染。
The author of interest traced blood recipients of more than 20,000 units to identify infections transmitted by blood transfusions. Design follow-up investigation of recipients. Background 22 hospitals north of London. Participants Recent transfusions of adult patients. The main results of blood samples were collected 9 months after blood transfusion recipients, detection of HCV, HBV, HIV and HTLV-Ⅰ, type Ⅱ infection markers. Differentiate between a recent infection or a pre-transfusion infection by comparing blood samples collected prior to transfusion. Results 9,920 patients were tested. A total of 5,579 recipients of 21,923 units of blood were followed, but no transfusion-transmitted infections were detected. For hepatitis B, blood transfusion spread was 0 in 21,043 units of blood (95% confidence interval, 5,706 recipients with a risk of transfusion infection of 0 to 1); hepatitis C was 0/21, 800 units of blood (transfusion infection risk 0 to 1 / 5,911 recipients); HIV was 0/21, 923 units of blood (0-1 / 5,944 blood transfusions without infection); HTLV was 0/21, 902 unit blood (blood transfusion infection risk was 0-1 / 5,939 recipients). Three patients were infected with hepatitis B during hospitalization and after hospitalization but were not shown to be infected by the transfusion route. Of the 176 patients (3%) who had been infected with hepatitis B before hospitalization, 16 (0.29%) were infected with hepatitis C and 5 (0.09%) were infected with HTLV. CONCLUSIONS: In the UK, there are currently very few infections transmitted by blood transfusions and more likely to be acquired than other routes of transfusion through the hospital. Infected patients are more previously acquired infections.