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Objective: To study the function of ce ll ular immunity in patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-typ e hypersensitivity (DTH) response to two recall antigens, tetanus toxoid (TT) an d purified protein derivative(PPD), were measured in five patients with HIE and 15 healthy controls, respectively. Results: The CD4+ cell cou nts in HIE group were significantly lower than those in control group (P<0. 01). In contrast, CD8+ cells were significantly higher than those in the contro l (P<0.01). The induration sizes of DTH response to two recall antigens wer e smaller in HIE group than those in the control group (P<0.01). Co nclusion: There was an immunologic dysfunction of T lymphocytes in the p atients with HIE.
Objective: To study the function of ce ll ular immunity in patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-typ e hypersensitivity (DTH) response to two recall antigens, tetanus toxoid (TT) an d purified protein derivative (PPD), were measured in five patients with HIE and 15 healthy controls, respectively. Results: The CD4 + cell courants in the HIE group were significantly lower than those in control group (P <0.01 ). In contrast, CD8 + cells were significantly higher than those in the contro l (P <0.01). The induration sizes of DTH response to two recall antigens wer e smaller in HIE group than those in the control group (P <0.01). Co nclusion: There was an immunologic dysfunction of T lymphocytes in the p atients with HIE.