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本文研究新制缓释18-甲基炔诺酮宫内节育器(LNGR-IUD)对大鼠子宫及主要脏器的影响。实验分四组:1.含药IUD组;2.不含药硅橡胶IUD组;3.手术对照组;4.正常对照组。结果表明,含药IUD组子宫内膜早期(15及30天时)有轻度炎症反应,60天时炎症反应逐渐消退,90天恢复正常。与不含药IUD组及手术对照组无差异。含药组子宫内膜呈乳头状增生与分泌,亦随时间延长而渐减轻。内膜血管仅早期呈现充血反应,30天后逐步消失。各组全身主要脏器皆未见病变,含药IUD组各期卵巢中见到正常卵泡发育及黄体形成。
The aim of this study was to investigate the effects of the delayed release 18-norgestrel IUD on the uterus and major organs in rats. The experiment was divided into four groups: 1. drug-containing IUD group; 2. silicone-free IUD group; 3. operation control group; 4. normal control group. The results showed that the IUD group had a mild inflammatory reaction in the early (15 and 30 days) endometrium, the inflammatory response gradually subsided 60 days and returned to normal after 90 days. No difference with non-drug IUD group and operation control group. Drug-containing group of endometrial papillary hyperplasia and secretion, but also with the passage of time and gradually reduced. Endometrial blood vessels showed only hyperemic reaction early, gradually disappear after 30 days. All the main organs of the whole body were not seen in the disease, the drug-containing IUD group found normal ovarian follicular development and corpus luteum formation.