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据Sun RC 2014年2月7日[Cell Metabol,2014,19(2):285-292.]报道,美国俄亥俄州立大学研究人员通过研究发现,癌细胞在氧气含量较低(缺氧状况)的肿瘤组织中依然存活生长,这对于开发逆转缺氧相关路径从而来抑制肿瘤生长的新型制剂提供了新的思路。研究人员揭示了癌细胞如何使用氨基酸-谷氨酰胺,其是一种在血液中常见的游离氨基酸;低于正常氧气含量水平时,健康的细胞会大量使用谷氨酰胺来产生能量,其中有很少量的谷氨酰胺转化成为脂肪酸和脂质。但当氧气含量在生长中的肿瘤中下降时,缺氧状况就会激活一种名为HIF1的基因,从而开启一种路径,这种路径并不会将谷氨酰胺转化成能量,而会合成细胞增殖所
According to a report by Sun RC on February 7, 2014 [Cell Metabol, 2014, 19 (2): 285-292.], Researchers at Ohio State University in the United States found that cancer cells in the lower oxygen content (hypoxic condition) The survival of tumor tissue is still alive, which provides a new idea for the development of new formulations that reverse the pathways associated with hypoxia and thereby inhibit tumor growth. Researchers have uncovered how cancer cells use amino-glutamine, a free amino acid commonly found in the bloodstream; healthy cells use large amounts of glutamine below normal oxygen levels to produce energy, including Small amounts of glutamine are converted to fatty acids and lipids. But as oxygen levels fall in growing tumors, hypoxia activates a gene called HIF1, opening up a pathway that does not convert glutamine into energy but synthesizes Cell proliferation