接种量、媒介控制以及虫株特异性免疫与疟疾发病的关系

• 作 者: Lines Jmstrong JRM 金立中
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1993年04期
• 关键词: 特异性免疫 接种量 子孢子 危重程度 疟区 带虫者 原虫感染 原虫血症 重复感染 儿童死亡率

在重度传播区促使疟疾发病的因素是什么?一种假设认为疟疾的危重程度取决于子孢子的接种量。而本文认为疟疾的天然免疫力具有虫株特异性;只有在株特异性的情况下,一次子孢子接种量的大小才有重要意义。只要存在虫株特异性免疫,那么仅仅根据媒介控制的近期效果就有可能对其长远效果作出过高的评价。

What are the contributing factors to the incidence of malaria in areas of severe transmission? One hypothesis is that the severity of malaria depends on the amount of sporozoites inoculated. In this paper, the natural immunity of malaria is considered to be strain-specific. Only in the case of strain specificity, the size of primary inoculation is significant. As long as strain-specific immunity is present, the long-term effects of the vector alone may be overestimated based only on the near-term effects of vector control.