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本文实验表明反相高效液相色谱流动相组成与头孢菌素容量因子成线性关系,并测定了头孢菌素的过量热力学函数△(?)～·,证明头孢菌素类药物的生物活性与△(?)～·存在定量构效关系.从而提出△(?)～·和△(?)～·分别是研究药物定量构效关系和药物生化过程的重要参数之一.
The experimental results show that the mobile phase composition of reversed-phase high-performance liquid chromatography has a linear relationship with the cephalosporin capacity factor, and the excess thermodynamic function △ (?) ~ · Of the cephalosporin has been determined, demonstrating the biological activity of the cephalosporins and △ (?) ~ · There is a quantitative structure-activity relationship, thus △ (△) ~ · △ and △ (△) ~ · are one of the important parameters for studying the QSAR and drug biochemical process.