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骨髓增生异常综合征(myelodysplastic syndromes,MDS)是一组克隆性造血紊乱的异质组群,以外周血细胞减少、发育异常和易于向白血病转化为特点。MDS的发生是个多步骤过程.干细胞水平的突变导致了遗传不稳定的细胞出现克隆性改变,并逐渐形成增殖优势。40%～70%的MDS患者可检出重现性克隆性染色体异常,为通过标准核型分析或间期荧光原位杂交(fluorescent in situ hybridization,FISH)定位被恶性克隆累及的细胞水平提供了可能。目前,对于MDS异常克隆起源于细胞分化哪一阶段尚无定论,国内外很多
Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic disorders characterized by reduced peripheral blood cells, dysplasia, and susceptibility to leukemia. The occurrence of MDS is a multi-step process.Changes in stem cell levels lead to clonal changes in genetically unstable cells and to a proliferative advantage. Reproducible clonal chromosomal abnormalities are detectable in 40% to 70% of MDS patients and provide the basis for mapping cellular levels involved in malignant clonalization by standard karyotyping or by fluorescence in situ hybridization (FISH) may. At present, there is no conclusion about which phase of MDS abnormal cell cloning originated in cell differentiation. Many domestic and foreign