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骆驼蓬(Peganum harmala L)系蒺藜科多年生草本植物,药用其种子。该药含有骆驼蓬碱(Harmaline)、去氢骆驼蓬碱(Harmine)、去甲基骆驼蓬碱(Harmalol)及鸭嘴花碱(Vasicine)等有效成份。药理试验证明,骆驼蓬碱和去氢骆驼蓬碱对多种瘤株均有明显的抑制作用。临床常用剂型为片剂及注射剂,经多年临床验证,能改善消化道恶性肿瘤病人的临床症状,并具有使用安全,毒副作用小等特点。本文对新疆医学院二附院研制的骆驼蓬总碱注射液进行了兔体内药物动力学研究,探讨其体
Peganum harmala L is a perennial herb of the family Chenopodiaceae, medicinal its seeds. The drug contains Harmaline, Harmine, Harmalol and Vasicine. Pharmacological experiments show that harmalaide and harmalachin on a variety of tumor strains were significantly inhibited. Clinical dosage forms for tablets and injections, after years of clinical validation, can improve the clinical symptoms of patients with gastrointestinal cancer, and has the use of safety, small side effects and other characteristics. In this paper, the Second Hospital of Xinjiang Medical University developed Peganum harmala total alkaloids in rabbits pharmacokinetics studies to explore the body