论文部分内容阅读
活性羰基化合物一直以来被人们称为致癌物和人类毒物,当其浓度升高时,会导致多种疾病,因此,设计开发用于选择性识别和高灵敏检测生物体内的活性羰基化合物的技术具有十分重要的意义.近年来,荧光探针具有操作简单、灵敏度高、选择性好,响应时间短以及能实现实时检测等优势,在活性羰基化合物及其他活性物种如活性氧、活性氮、次氯酸以及硫醇等物质的检测方面获得了快速发展.鉴于活性羰基化合物荧光探针综述方面的报道很少,从探针分子与待测物之间发生的反应类别进行归纳和总结,概括了甲醛、甲基乙二醛、丙二醛以及丙烯醛等活性羰基化合物的荧光探针,并从设计理念、识别机理以及应用等方面进行了描述,还对活性羰基化合物荧光探针的设计和应用前景提出了展望.
Activated carbonyl compounds have long been known as carcinogens and human poisons. When their concentration is increased, they lead to many diseases. Therefore, the technology designed to selectively recognize and highly sensitively detect active carbonyl compounds in a living organism has It has very important meaning.In recent years, fluorescent probe has the advantages of simple operation, high sensitivity, good selectivity, short response time and the ability to achieve real-time detection and other advantages in the active carbonyl compounds and other active species such as reactive oxygen species, reactive nitrogen, Acid and mercaptan.As the report of the summary of active carbonyl compounds fluorescent probes is rare, the reaction types between probe molecules and analytes are summarized and summarized, and the formaldehyde , Methylglyoxal, malondialdehyde and acrolein and other active carbonyl compounds of fluorescent probes, and from the design concept, identification mechanism and application of such aspects are described, but also for the active carbonyl compound fluorescent probe design and application prospects Put forward the prospect.