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在复制鼠脑缺血再灌注损伤模型的基础上，利用亚低温作为治疗手段，观察亚低温对鼠脑缺血再灌注损伤的保护作用及其对氧自由基的影响。结果发现：亚低温度（３３℃、３０℃）能降低脑缺血再灌注性损伤脑皮质的水肿程度，减少ＭＤＡ产生，保护ＳＯＤ活力，且以３０℃低温作用更为显著。结果提示：亚低温对鼠脑缺血再灌注损伤具有保护作用，且随低温程度加深而增强；同时提示，抑制自由基产生，保护ＳＯＤ活力可能为亚低温保护作用机制之一
On the basis of replicating rat model of cerebral ischemia-reperfusion injury, we used mild hypothermia as a therapeutic measure to observe the protective effect of mild hypothermia on cerebral ischemia-reperfusion injury and its effect on oxygen free radicals. The results showed that sub-low temperature (33 ℃, 30 ℃) could reduce cerebral edema, reduce the production of MDA and protect the activity of SOD in cerebral ischemia-reperfusion injury, especially at 30 ℃. The results suggest that mild hypothermia has a protective effect on cerebral ischemia-reperfusion injury and increases with the deepening of the degree of hypothermia; meanwhile, it is suggested that the inhibition of free radical production and protection of SOD activity may be one of the mechanisms of hypothermia protection