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本文报道了异三尖杉酯碱侧链酸(3)的立体选择性合成。(R,R)-(+)-酒石酸先制成酒石酸二甲酯缩丙酮(8),然后经烷基化、构型转换、催化加氢、碱性水解、部分酯化和酸性水解,首次成功地得到了预期产物3。
This paper reports the stereoselective synthesis of homoharringtonine side chain acid (3). (8) from dimethyl (R, R) - (+) - tartaric acid and then alkylated, Successfully got the expected product 3.