论文部分内容阅读
目的了解月见草油一次大量食用是否安全;是否具有遗传毒性。方法按照GB15193-2003的程序和方法,采用急性经口毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验及小鼠精子畸形试验,观察小鼠急性中毒症状和死亡情况;原核细胞、体细胞、生殖细胞的致突变作用。结果月见草油的急性经口LD50>20.0 g/kg·bw;三项遗传毒性试验结果均为阴性。结论在本实验条件下,月见草油属无毒级,未见对原核细胞、体细胞、生殖细胞具有遗传毒性作用。
Objective To understand whether a large amount of evening primrose oil is safe and whether it is genotoxic. Methods Acute oral toxicity test, Ames test, mouse bone marrow polychromatic erythrocytes micronucleus test and mouse sperm abnormality test were used to observe the symptoms and death of mice acute poisoning according to the procedure and method of GB15193-2003. The prokaryotic cells, Somatic cells, germ cell mutagenicity. Result The oral LD50 of evening primrose oil was> 20.0 g / kg · bw. The results of three genotoxicity tests were negative. Conclusion Under the experimental conditions, the evening primrose oil is non-toxic grade, no genetic toxicity to prokaryotes, somatic cells and germ cells.