叶酸、维生素B6、维生素B12与冠心病的防治

• 作 者: 林梓卿 吴同果
• 机 构: 广州市红十字会医院心血管内科,广州市红十字会医院心血管内科 广州510220,广州510220
• 出 处: 岭南心血管病杂志
• 发表日期: 2006年02期
• 关键词: 叶酸 维生素B6 维生素Bi2 冠心病

高同型半胱氨酸血症已被证实为冠心病的独立危险因子,但以叶酸为基础的联合维生素B6、B12降低同型半胱氨酸疗法在冠心病防治中作用尚有争论。研究提示该方案可明显降低同型半胱氨酸水平,并可改善血管内皮功能,调节血小板聚集,抗氧化应激所介导的细胞凋亡。但在临床试验中有着不同结论,本综述拟介绍叶酸、维生素B6、B12与同型半胱氨酸的代谢关系及该方案在冠心病防治中作用的研究进展。

Hyperhomocysteinemia has been identified as an independent risk factor for coronary heart disease, but the combination of folic acid-based vitamin B6 and B12 to reduce the role of homocysteine ​​in the prevention and treatment of coronary heart disease is still controversial. Research suggests that the program can significantly reduce homocysteine ​​levels, and can improve endothelial function, regulate platelet aggregation, anti-oxidative stress-mediated apoptosis. But in clinical trials have different conclusions, this review will introduce the metabolic relationship between folic acid, vitamin B6, B12 and homocysteine ​​and the progress of the program in the prevention and treatment of coronary heart disease.